Direct answers to GLP-1 questions
Short-answer-first explanations to the questions people actually search for. Each entry links to deeper clinical-grade context.
- Why am I not losing weight on GLP-1?
Most non-responders are eating more calories than they realize, are still in the titration window, are under-dosed, or have hit a metabolic plateau. True non-response to the medication itself is uncommon.
- What is the GLP-1 side effects timeline?
Most GI side effects appear 24–72 hours after each dose increase and improve substantially within 4–8 weeks of holding a stable dose. Serious effects (pancreatitis, gallbladder issues) are uncommon but require urgent care.
- Can I drink alcohol on GLP-1?
Alcohol is not contraindicated but is poorly tolerated on GLP-1s. Most users report stronger effects from less alcohol, worse next-day GI symptoms, and slower weight loss when drinking regularly.
- What happens when you stop GLP-1?
Appetite returns within 1–4 weeks and most people regain a portion of lost weight without lifestyle scaffolding. The STEP-4 extension showed ~two-thirds of lost weight was regained within a year of stopping semaglutide.
- What is the standard semaglutide dosage schedule?
The 5-step weekly titration: 0.25 → 0.5 → 1.0 → 1.7 → 2.4 mg.
- How much protein should I eat on GLP-1?
Target 1.2–1.6 g/kg body weight to preserve lean mass.
- How do I break a GLP-1 plateau?
What the evidence supports when weight loss stalls at month 6–9.
- How do I manage nausea on GLP-1?
Why it happens, when it peaks, and the moves that actually help.
- Semaglutide vs tirzepatide — which is better?
Head-to-head trial efficacy and tradeoffs.