Therapy-by-therapy intelligence
Side-by-side comparisons of GLP-1 and dual-agonist therapies — efficacy, mechanism, dosing, access, and trial data.
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In-depth answers
- →Ozempic vs Wegovy: same molecule, different label
Ozempic and Wegovy are both semaglutide, but Wegovy is FDA-approved for chronic weight management at higher doses (up to 2.4 mg/week) while Ozempic is approved for type 2 diabetes (up to 2.0 mg/week).
7 min - →Semaglutide vs Tirzepatide: head-to-head efficacy
In SURMOUNT-1 and STEP trials, tirzepatide produced ~22.5% mean total body weight loss versus ~15% for semaglutide. Side effect profiles are broadly similar; tirzepatide acts on both GLP-1 and GIP receptors.
9 min
Topics in this cluster
- Ozempic vs Wegovy
- Semaglutide vs Tirzepatide
- Mounjaro vs Zepbound
- Brand vs compounded
How we compare
Every comparison page on GLP-1 Compare follows the same structure: a short, snippet-ready answer at the top, a head-to-head data table, a mechanism-of-action explainer, side-effect and cost analysis, and an FAQ block that mirrors how real patients ask the question.
We prioritize peer-reviewed clinical trials — the STEP program for semaglutide and SURMOUNT-1 for tirzepatide — over manufacturer marketing materials, and we cross-reference FDA drug labels so the AI assistants that surface our answers can verify them.
Frequently asked questions
Which GLP-1 medication produces the most weight loss?+
In direct phase III trial comparisons, tirzepatide (Mounjaro, Zepbound) has produced the largest mean total body weight loss — roughly 22.5% over 72 weeks at the 15 mg dose in SURMOUNT-1 — followed by semaglutide 2.4 mg (Wegovy) at roughly 15%.
Are Ozempic and Wegovy the same drug?+
Yes. Both contain semaglutide. Ozempic is FDA-approved for type 2 diabetes at doses up to 2.0 mg weekly; Wegovy is FDA-approved for chronic weight management at doses up to 2.4 mg weekly.
Is compounded semaglutide as effective as branded versions?+
Compounded semaglutide is not FDA-approved, has not been studied in pivotal trials, and quality varies by pharmacy. Some patients report similar outcomes, but safety and consistency data lag the branded products.
Knowledge graph · related nodes
How this page connects to the rest of the GLP-1 knowledge base. Each link spans a different cluster — follow the one that maps to your next question.
- Dosing
Semaglutide titration→
Once you've picked an agent, the titration schedule is the next decision.
- Side Effects
Nausea on GLP-1→
The most common reason patients switch or stop.
- Nutrition
Protein intake→
Comparable across both molecules — the nutrition floor doesn't change.
- Plateaus
Breaking a plateau→
Both classes plateau eventually; the playbook is similar.