Foundations for your first 12 weeks
A structured introduction to GLP-1 therapy — what it is, how it works, what to expect in the first weeks, and how to set yourself up for sustainable results.
Understand the mechanism
GLP-1 is an incretin hormone your gut releases after meals. The therapy mimics that signal — slowing gastric emptying, increasing satiety, and modulating insulin. Knowing the mechanism makes every other decision (dose, timing, food) much easier.
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Pick the right medication
Semaglutide (Ozempic/Wegovy) and tirzepatide (Mounjaro/Zepbound) are the dominant options. They differ in mechanism, efficacy, and label — and the right choice often depends on insurance, comorbidities, and tolerance.
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Master the titration ramp
Almost all side effects are dose-related. The standard semaglutide ramp moves through five doses over 16+ weeks. Going slower than the label is normal and often improves outcomes.
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Build the nutrition foundation
Appetite drops fast. The risk in week 1–8 isn't eating too much — it's not eating enough protein. Aim for 1.2–1.6 g/kg/day, spread across 3–4 meals.
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Anticipate the most common side effects
Nausea is universal and time-limited. Knowing what's normal, what isn't, and when to call your prescriber is the single biggest factor in staying on therapy.
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